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Thin Sectioning Application To determine the ultrastructure of whole tissues and cells at ~2nm resolution by transmission electron microscopy (TEM). Method Tissues or cells are chemically fixed, dehydrated, embedded in resin…

Starting immediately or as per agreement How does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate the entire spectrum ranging from the atom to…

Image Gallery To share your scientific images taken at the IMCF in this gallery, please send your images to Alexia with a short description. The images contained within this gallery remain the copyright of the Biozentrum.…

Research Projects Our team is comprised of people with different training: Some team members are trained in physics or mathematics, some are trained in molecular biology, and others are trained in interdisciplinary sciences…

IMCF guidelines 1. General booking Rules: The user can book a microscope only after having received the appropriate introduction. The instruments can be booked up to 14 days in advance. During daily working hours (9-17h),…

FEI Titan Krios TEM (300kV) Top left: Front protective enclosure of the Titan Krios. Top right: Detail of the microscope from inside the enclosure, showing the complexity of the microscope mainframe. Bottom: Operation…

Structure, function, and evolution of genome-wide regulatory networks Most projects that we pursue concern the functioning and evolution of genome-wide regulatory systems in organisms ranging from bacteria to humans. The…

Available Microscope Systems Searching for a decision tree? Clicking on the image below and you will be directed to our internal documentation that will help you to decide which system is best for your research project. If…

Chromosomes in 3D The developmentally dynamic nucleus How are chromosomes organized within nuclei? And how does organization impact developmental events? The nucleus is very dynamic during embryogenesis, in part because…

Computational structure biology Protein structure modeling The main interest of our group is the development of methods and algorithms for molecular modeling and simulations of three-dimensional protein structures and their…