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TOR signaling and control of cell growth Fig. 1: Architecture of human mTOR complex 1 Introduction Cell growth is highly regulated. Cells respond to nutrients or other appropriate growth stimuli by up-regulating…

How cells defend their cytosol against bacteria: LPS ubiquitylation and other tricks Intracellular pathogens colonize specific subcellular niches, reflecting the pathogen's need for host factors and nutrients as well as its…

Synopsis Antibiotic resistance has re-emerged as a critical problem of contemporary medicine. I will discuss the biological processes contributing to the spread of antibiotic resistance. In this talk, I will ask how…

Research projects We investigate the physiology of bacterial pathogens ( Salmonella , Pseudomonas , Staphylococcus ) in infected rodent and human tissues, focusing on single-cell behavior and potential applications for novel…

Muscle aging Rapid advances in treating life-threatening, age-related diseases, such as cancer and cardiovascular disease, have extended human lifespan in many developed countries. However, greater longevity has meant more…

We study the cellular organization and regulation of metabolism by large macromolecular assemblies as well as giant microbial biosynthetic assembly lines. Our research builds on hybrid use of state-of-the-art cryo electron…

Research Projects Our team is comprised of people with different training: Some team members are trained in physics or mathematics, some are trained in molecular biology, and others are trained in interdisciplinary sciences…

The blood vessels form a widely ramified supply system that passes through our body from head to toe. They serve as pathways for blood cells and transport oxygen as well as nutrients into each individual organ. In the…

Regulation of skeletal muscle cell plasticity in health and disease Skeletal muscle has an enormous capacity to adapt to external stimuli including physical activity, oxygen levels, ambient temperature, nutrient availability…

Cell Biology Lecture Series The "Cell Biology Lecture Series" is a joint effort of the Research Groups Affolter, Engel, Hall, Hondele, Rüegg, Schier and Spang to monthly host international speakers to talk about current…