Conservation of anti-viral immunity across domains of life All cells, eukaryotic and prokaryotic, face the threat of viral infections and develop anti-viral systems to fight them off. The constant arms race between cells and…

Keystone gut microbiota promoting pathobiont clearance by nutrition competition and microbiota recovering The mammalian gut microbiota plays a pivotal role in various aspects of host health, ranging from nutrition, immune…

A question of dynamics In response to different stimuli many transcription factors (TFs) display different activation dynamics that trigger the expression of specific sets of target genes, suggesting that promoters have a…

Pathogenesis and treatment of Enterococcal biofilm-associated infections The Gram-positive Enterococci are commensal inhabitants of the gastrointestinal tract, as well as opportunistic pathogens associated with endocarditis,…

Dynamics of the peptidoglycan synthesis machinery during Staphylococcus aureus cell division Bacterial cell division is mediated by the tubulin-homolog FtsZ which recruits peptidoglycan (PG) synthesis enzymes to the division…

Surface tension: the battle for bacterial supremacy at the human urothelial interface Despite its initial appearance as a straightforward bacterial infection, urinary tract infection (UTI) presents a perplexing challenge, as…

Navigating Ageing Through Omic Layers Ageing and its associated diseases are influenced by a complex interplay of genetics, lifestyle,environment, and increasingly recognized, the microbiome. Understanding these…

Mucosal immunity in the bladder Urinary tract infections (UTI) are the second most common infection, impacting nearly 50% of all women. Indeed, otherwise healthy, premenopausal women have a significantly greater incidence of…

Using Cryo-Electron Tomography to establish the determinants of COPII-mediated membrane remodeling COPII mediates Endoplasmic Reticulum to Golgi trafficking of thousands of cargoes. Five essential proteins assemble into a…