Denis Schapiro (Heidelberg University Hospital) specializes in spatial omics and highly multiplexed imaging to profile single cells within their tissue context. His work aims to enhance understanding, diagnosis, and treatment of tissue-based diseases like cancer through innovative computational and experimental tools. He developed widely used software such as histoCAT and MCMICRO for analyzing and visualizing multiplexed imaging and spatial omics data. His current research focuses on advancing imaging technologies and creating open-source computational pipelines that incorporate machine learning. These pipelines are intended for biomarker discovery, integrating spatial omics with in vivo drug screening to connect tissue architecture and therapeutic response, and establishing standards for experimental design and data sharing in multiplexed tissue imaging. The lab’s interdisciplinary approach combines computational biology, pathology, and systems pharmacology to drive progress in spatial single-cell biology and digital pathology.