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Biozentrum Discovery Seminars

Biozentrum Discovery (BZD) is a seminar series, which alternates between talks by invited speakers from other institutions and seminars given by graduate students and postdocs from the Biozentrum. Since its establishment in 2018, the following seminars have taken place:  

May 12, 2023 (lecture hall U1.131)

“The small GTPase Arf1 maintains mitochondrial bioenergetics by modulating fatty acid metabolism”
Ludovic Enkeler (group Anne Spang)

“The chosen ones: How a few specialized nuclei maintain the muscle synapse”
Alexander Ham (group Markus Rüegg)

May 5, 2023 (lecture hall U1.131)
"Super-resolution imaging of transcription in living cells"

Prof. Ibrahim Cissé 
Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
April 28, 2023 (lecture hall U1.131; 1:00 pm)
"Engineering epithelial organoid development"

Prof. Matthias Lütolf 
EPFL and Roche Institute for Translational Bioengineering, Switzerland
April 21, 2023 (Maurice E. Müller lecture hall)
"Invincible? Surviving Staphylococcus aureus in human deep-seated infections"
Vishwachi Tripathi (group Dirk Bumann)

"Lost in 'co' translation: How a once thought tissue-specific RP paralog widely affects protein stability and degradation"
Arka Banerjee (group Mihaela Zavolan)
March 24, 2023 (lecture hall U1.131)
"The functional cycle of the human Hsp70 chaperone BiP at atomic resolution"
Guillaume Mas (group Sebastian Hiller)

"Engineered kinases as a tool for phosphorylation of selected targets in vivo"
Katarzyna Lepeta (group Markus Affolter)

February 24, 2023 (lecture hall U1.131)
"Mitochondrial proteostasis in aged skeletal muscle"
Laura de Smalen (group Christoph Handschin)

"Dynamic mechanism of the nuclear pore complex permeability barrier"
Toshiya Kozai (group Rod Lim)

January 27, 2023 (lecture hall U1.131)
"Research acceleration with sciCORE scientific support services"
Geoffrey Fucile (sciCORE)

“Cortical control of forelimb movement” 
Wuzhuo Yang (group Silvia Arber)

December 9, 2022 (lecture hall U1.131)
"Development and evolution of visual projections"

Prof. Alain Chédotal, Vision Institute, INSERM, Paris
December 2, 2022 (lecture hall U1.131)
"Single-cell analysis of bacterial gene expression dynamics during starvation"
Théo Gervais (group Erik van Nimwegen)

" 'I’m A Survivor': The mechanisms of drug tolerance in a human pathogen"
Isabella Santi (group Urs Jenal) 
November 4, 2022 (lecture hall U1.131)
"TreeKnit: Inferring Ancestral Reassortment Graphs of influenza viruses"
Pierre Barrat (group Richard Neher)

“Adipose mTORC2 is essential for sensory innervation in white adipose tissue”
Irina Frei (group Mike Hall)
September 30, 2022 (lecture hall U1.131)
"Keeping the balance: A role for Bone Morphogenic Proteins in controlling neuronal networks"
Zeynep Okur (group Peter Scheiffele)

"Genomics Facility Basel - Technologies, Applications & Opportunities"
Christian Beisel (Genomics Core Facility)
September 23, 2022 (lecture hall U1.131)
"Stem cell-derived organoids model human disease"

Prof. Hans Clevers, Head pRED Roche, Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, NL

August 19, 2022 (zoom and U1.131)
"Polarized secretion from killer cells of the immune system"

Prof. Gillian M. Griffiths, Cambridge Institute for Medical Research, Cambridge, UK

June 17, 2022 (lecture hall U1.131)
"Exploring behavioral functions of human sleep disorder genes"
Will Joo (group Alex Schier)

“Give it a shot! – A bacterial nanoweapon for a silent spread inside eukaryotic cells” 
Miro Plum (group Marek Basler)
June 3, 2022 (zoom and lecture hall U 1.131)
"Nanobacteria: Key players in the earth’s carbon cycle"
Prof. Stephen Giovannoni, Oregon State University
May 13, 2022 (zoom and lecture hall U 1.131)
"Studying host-microbiome ecology in humans using mathematical models and data collected from hospitalized patients"
Dr. Joao Xavier, Memorial Sloan Kettering Cancer Center, New York
April 22, 2022 (zoom and lecture hall U1.141)
"SEEDing the genome to manipulate the proteome. A novel method for scarless gene tagging"
Gustavo Aguilar (group Markus Affolter)

"Setting an Evolutionary Trap with Phages"
Anouk Bertola (group Médéric Diard)

April 1, 2022 (zoom and lecture hall U1.131)
"Decoding Transcriptional Processes and Kinetics with Single-Cell Transcriptomics"

Prof. Rickard Sandberg, Karolinska Institute, Stockholm, Sweden
Host: Attila Becskei

March 25, 2022 (zoom and lecture hall U1.131)
“An AAV/CRISPR tool for functional gene interrogation in adult skeletal muscle”
Marco Thürkauf (group Markus Rüegg)

"T3 Pharma - bugs as drugs"
Christoph Kasper (T3 Pharmaceuticals)

March 18, 2022 (lecture hall U1.131 and zoom)
"Spatial transcriptomics/genomics: dissecting the neurobiology of olfaction"

Prof. Bogdan Bintu, University of California San Diego
Host: Alex Schier

February 25, 2022 (zoom or Lecture Hall U1.131)
"Emergent properties of bacterial swarming behavior"
Hannah Jeckel (group Knut Drescher)

"Mechanistic insights into the regulation of Neurofibromin, a molecular switch of cellular proliferation"
Malik Chaker-Margot (group Timm Maier)

POSTPONED: December 3, 2021 (zoom and Maurice E. Müller Lecture Hall)
"Development and evolution of visual projections"

Dr. Alain Chédotal, Institut de la Vision, Paris
Host: Flavio Donato

November 25, 2021 (zoom and Maurice E. Müller Lecture Hall)  
“Germ cell migration: Finding the path toward immortality”

Prof. Ruth Lehmann, Director, Whitehead Institute, MIT
Host: Alex Schier

November 19, 2021 (zoom)
“Mapping high-resolution cell states in single-cell RNA-seq data”
Pascal Grobecker (group van Nimwegen)

"How microRNAs regulate stem cell proliferation and fate decisions in the adult stem cell niche"
Fabrizio Favaloro (group Doetsch)

October 29, 2021 (zoom and Lecture Hall U1.131)
“Cooperation, competition and warfare in bacteria: from model systems to the microbiome”

Prof. Kevin Foster, University of Oxford, Oxford, UK,
Host: Médéric Diard

October 22, 2021 (zoom)
"Shortening of 3’ UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism"
Dominik Burri (group Zavolan)  

“Cryo-ET: The Power of Visualizing Cellular Processes in situ at Nanoscale”
Dr. Ashraf Al-Amoudi (group Maier)   

October 15, 2021 (zoom)
"The RNA exosome complex: the Dr Jekyll and Mr Hyde of RNA degradation"

Prof. Elena Conti, Max Planck Institute of Biochemistry, Martinsried, Germany
Host: Camilo Perez 

September 24, 2021 (zoom)

“Mechanistic basis of choline import involved in pneumococcal teichoic acid modification"
Natalie Baerland  (group Perez) 

"Midbrain locomotor region involved in more than just locomotion"
Harsh Kanodia (group Arber)

June 25, 2021 (zoom webinar)
"From bacteriophage defense systems to novel genetic tools and back"
David Bikard, Institut Pasteur, Paris, France
June 18, 2021 (zoom webinar)
"Deciphering mechanisms of human brain size determination using cerebral organoids"
Madeline Lancaster, MRC Lab of Molecular Biology, Cambridge
June 11, 2021 (internal, via zoom)
"Sense, aim and fire - bacterial response to cell-cell contact"
Lin Lin (Basler group)

"Diving into the zone of uncertainty, its role in fear learning"
Ed Li (Zan group)
May 28, 2021 (zoom webinar)
"Mitotic chromosome mechanics"
Daniel Gerlich, Institute of Molecular Biotechnology (IMBA), Vienna, Austria
May 21, 2021 (zoom webinar)
"Barcoding the structural proteome"
Paola Picotti, ETH Zurich
April 30, 2021 (internal, via zoom)
"Topogenesis of membrane proteins: more than hydrophobicity"
Marco Janoschke (Spiess group)

"Karyopherin composition alters nuclear pore complex barrier function"
Joanna Kalita (Lim group)
April 16, 2021 (zoom webinar) 11:15 am
"Brain mitochondria and metabolism on the links between stress, anxiety and motivation"
Carmen Sandi, EPFL, Lausanne
April 9, 2021 (zoom webinar) - cancelled
"Explorations of brain dynamics in reptilian sleep and cuttlefish camouflage"
Gilles Laurent, Director, Max Planck Institute for Brain Research, Frankfurt a. M., Germany
March 26, 2021 (zoom webinar)
"Combinatorial action of temporally segregated transcription factors as a mechanism for cell diversification"
Luisa Cochella, Research Institute of Molecular Pathology, Vienna, Austria
March 19, 2021 (zoom webinar)
"Tasting from within: a new sensory interface with the cerebrospinal fluid"
Claire Wyart, Institut du Cerveau et de la Moelle epiniere, ICM, Paris
March 12, 2021 (zoom webinar)
" 'Zoom'ing in on organelle communication - systematic exploration of contact sites"
Maya Schuldiner, Weizmann Institute of Science, Rehovot, Israel
March 5, 2021 (via zoom)
"Manipulation of host protective immune activation by pathogenic mycobacteria"
Tan Hop Huynh (Pieters group)

"Gene families with stochastic exclusive gene choice underlie cell adhesion in mammalian cells"
Simone Faravelli (Becskei group)
February 19, 2021 (zoom webinar)
"Genome regulation during developmental transitions: New views of old questions"
Eileen Furlong, EMBL Heidelberg
February 12, 2021 (via zoom)
"A switch protein generates bimodal distribution of nucleotide second messenger"
Margo van Berkum (Jenal group)

"Research Instrumentation - A new core for the NBZ"
Ludovit Zweifel (Biophysics Facility)
February 5, 2021 (zoom webinar)
"Synthetic Developmental Biology - Interspecies comparison and manipulation of organoids"
Miki Ebisuya, EMBL Barcelona
January 29, 2021 (via zoom)
"Cell-type specialization is encoded by specific 3D genome structures"
Ana Pombo, Max Delbrück Center for Molecular Medicine, Berlin
December 11, 2020 (via zoom)
"Inhibitor or substrate? Getting the answer through structural biology"
Dongchun Ni (Stahlberg group)

"Unleashing the therapeutic potential of mTOR inhibition"
Stefan Imseng (Aukera)
November 20, 2020 (via zoom)
"A tale of two fish: how gene family evolution underlies cell type diversification"
Dr. Max Shafer (Group Schier)

"Chopsticks to produce bacterial second messenger"
Dr. Raphael Teixeira (Group Schirmer)
October 16, 2020 (via zoom)
"Distinct roles of Dpp/BMP morphogen dispersal and signaling during Drosophila wing development"
Dr. Shinya Matsuda (Affolter group)

"Arginine promotes liver cancer"
Dr. Dirk Mossmann (Hall group)
September 18, 2020 (via zoom)
"Transient interactions in the early wiring of cortical circuits: from neuronal guideposts to immune cells"
Sonia Garel, Institut de Biologie de l'Ecole Normale Superiore, IBENS, Paris; Host: Fiona Doetsch
September 11, 2020 (via zoom)
"From membrane repair to metabolism – unexpected insights from a muscular dystrophy"
Dr. Regula Furrer, Group Christoph Handschin

"High pressure switches ß1-adrenergic receptor to the active state in the absence of G protein"
Dr. Layara Abiko, Group Stephan Grzesiek
July 3, 2020 (via zoom)
Ninja Warrior: How a bacterial pathogen hijacks host signaling
Dr. Isabel Sorg, Group Christoph Dehio

The dynamic brain of a future mother: adult neurogenesis during pregnancy
Dr. Zayna Chaker, Group Fiona Doetsch
June 19, 2020 (via zoom)
Diverse organization & lamina-induced stretching of embryonic chromosomes
Dr. Ahilya N. Sawh, Group Susan Mango

Technology news from Biophysics, FACS and Imaging Core Facilities
Tim Sharpe, Janine Bögli and Alexia Loynton
June 5, 2020 (via zoom)
Eating and self-eating: targeting autophagy to endosomes
Dr. Valentina Millarte, Group Martin Spiess

The dynamic mechanism of 4E-BP1 recognition by mTORC1
Dr. Raphael Böhm, Group Sebastian Hiller
May 15, 2020 (via zoom)
Restoring muscle scaffolding for a stable future: Towards a gene therapy for LAMA2 neuromuscular disease
Dr. Judith Reinhard, Group Markus Rüegg

FERARI: a platform involved in endocytic recycling
Harun-Or Rashid, Group Anne Spang
February 21, 2020
Proteomics is coming of age - can it retire the Western Blot?
Dr. Alexander Schmidt, Head Proteomics Core Facility

Bacterial kinase activation by second messenger induced domain liberation
Elia Agustoni, Group Tilman Schirmer
December 6, 2019
Less is more when it comes to mTORC1 and muscle aging, 
Dr. Daniel Ham, Group Markus Rüegg

The transcriptional biography of developing tissues
Dr. Yiqun Wang, Group Alex Schier
November 28, 2019, 4:15 pm
Sorting of small RNAs for secretion in human exosomes,
Nobel laureate Prof. Randy Schekman, University of California, Berkeley 
Host: Anne Spang
November 8, 2019
Observing bacterial pathogen evolution with long read sequencing, 
Dr. Nicholas Noll, Group Richard Neher

Control of neuronal synapse specification by alternative splicing, 
Dr. Lisa Traunmüller, Group Peter Scheiffele
October 21, 2019
Dynamic structural biology: Bringing the structures of nucleic acids to life, Prof. Hashim M. Al-Hashimi, Duke University, Host: Stephan Grzesiek
October 4, 2019
"Heterogeneity in host-pathogen encounters: single cell activities of Salmonella in infected host tissues", Francesca Cianfanelli, Group Dirk Bumann

"Identifying a good animal model for age-related muscle loss in humans", Anastasiya Börsch, Group Mihaela Zavolan
September 27, 2019
"The self-assembling brain - through the eye of a fly", Prof. Robin Hiesinger, Institute of Biology, Free University Berlin, Host: Peter Scheiffele
September 6, 2019
"A.I. in microscopy: Deep learning in image restoration and analysis", Oliver Bielmaier, IMCF

"Targeting Coronin 1 to kill and tolerate", Rajesh Jayachandran, Group Jean Pieters
June 21, 2019
"The first steps in vision: cell types, circuits and repair", Prof. Botond Roska, Director Institute of Molecular and Clinical Ophthalmology Basel (IOB) Host:Fiona Doetsch
June 7, 2019
"Brainstem circuits for diversification of skilled forelimb movements", Ludwig Ruder, Group Silvia Arber

"Finding n.e.m.o. RNAi" Jadiel Wasson, Group Susan Mango
May 3, 2019
"Going too fast to notice anything", Thomas Julou, Group Erik van Nimwegen

"When death is not enough: The evolution of the T6SS as a lytic weapon in microbial warfare", Andrea Vettiger, Group Marek Basler
March 29, 2019
"The structure of discoidal high-density lipoprotein particles", Stefan Bibow, Group Sebastian Hiller

"PERsuading muscle to move around the clock", Julien Delezie, Group Christoph Handschin

February 22, 2019
"Fat, friend or foe?: Regulation of glucose homeostasis", Mitsugu Shimobayashi, Group Michael Hall

"Fat: friend and foe! How cholesterol fine tuning is required for development", Carla Cadena del Castillo, Group Anne Spang

February 1, 2019
"Long-term single cell quantification: New tools for old questions", Prof. Timm Schroeder, D-BSSE, ETH Zurich, Host: Prof. Fiona Doetsch
December 7, 2018
"Should I stay or should I go: Bacterial decision-making for host colonization", Benoit Laventie, Group Urs Jenal

"Motivation to socialize: Recognizing others through reward", Hanna Hörnberg, Group Peter Scheiffele
November 27, 2018
"How synapses work: Architecture and mechanisms of neurotransmitter receptors and transporters", Eric Gouaux, Vollum Institute, OHSU, USA, Host: Camilo Perez