PhD Position: High-throughput multiplexed microfluidics for antimicrobial drug discovery
100%, starting upon mutual agreement, duration: 4 year
The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.
We are looking to recruit a highly motivated PhD student to join the van Nimwegen group. The van Nimwegen group is a interdisciplinary group of researchers with backgrounds ranging from theoretical physics to molecular biology that study the structure, function, and evolution of gene regulatory networks that control gene expression.
The project is a collaboration between the van Nimwegen research group at the Biozentrum and the Laboratory for Micro- and Nanotechnology at the PSI.
The main goal of the project is to develop a new method for high-throughput quantification of the effects of antimicrobial compounds on single cells as a function of their physiological state. In the first phase of the project you will develop new microfluic designs that allow arrays of strains and treatments to be assayed in parallel, building on existing prototypes that have already been developed in the van Nimwegen lab. These designs will involve fabrication of channels with sub-micrometer dimensions and thus the use of electron beam lithography. The fabrication will be carried out at the PSI where, besides optical UV lithography, high resolution e-beam direct writing tools are available for defining high aspect ratio micro- and nanometer structures of arbitrary shape. For more information about this project:
We expect candidates for the position to have a relevant experimental background, e.g. in biophysics, soft matter physics, or in a comparable quantitative biology field, and to have a particular interest in pursuing the topics described above using quantitative experimental approaches in combination with advanced computational and theoretical analysis. Preference will be given to candidates willing to start early.
The selected PhD candidate will become a junior member of the SNI and benefit from personal support, a strongly interdisciplinary social environment, training in soft skills offered by the PhD program and many internal SNI events.
Application / contact
Applications should be made by sending a CV, application letter and contacts of two references to Prof. E. van Nimwegen at: erik.vannimwegen(at)unibas .ch
Main PI: Prof. Dr. Erik van Nimwegen, Biozentrum, University of Basel & SIB
Co-PI: Dr. Vitaliy Guzenko, Paul Scherer Institut