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Postdoctoral Researcher (100%)

Evolutionary Principles of Intestinal Microbiota/Entero-Pathogen Interactions

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world, and is the largest department at the University of Basel’s Faculty of Science. It consists of more than 30 research groups and 500 employees from over 40 countries that research how molecules and cells create life, spanning the scale from atom to organism.  Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoctoral research position is available in the group of Prof. Médéric Diard at the Biozentrum, University of Basel. The Diard group is generally interested in exploring fundamental evolutionary aspects of virulence and microbial communities. 

Your responsibility will be to investigate how the interaction with the host microbiota affects the evolutionary dynamics of entero-pathogens. We will combine our expertise on experimental evolution of Salmonella Typhimurium 1-5 with well-established gnotobiotic mouse models 6 to address the interplay between evolvability of entero-pathogens, transmission and permissiveness of the intestinal microbiota.

Profile: 
Interested candidates should have a PhD degree with a genuine interest in molecular biology and evolution. A background in experimental infection biology in mouse models is advantageous. The successful candidate should exhibits team spirit, perseverance and a taste for multidisciplinary projects. Communication skills in oral and written English are essential.

We offer:
The Diard lab offers a vibrant scientific work environment with excellent infrastructure including state of the art animal facilities and benefits from strong collaborations within the institute and worldwide. Salary and benefits are attractive.
Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland- Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact:
Please send your completed application (including cover letter describing your past projects and interest in our lab, CV and contact information of two references to mederic.diard(at)unibasto make life hard for spam bots.ch. For further information, please also contact Prof. Diard directly.

Reviewing of applications will start May 1, 2020 and continue until the position is filled.

Related publications:

  1. Diard, M. et al. Stabilization of cooperative virulence by the expression of an avirulent phenotype. 
    Nature (2013)
  2. Diard, M. et al. Antibiotic treatment selects for cooperative virulence of salmonella typhimurium.
    Curr. Biol. (2014)
  3. Diard, M. et al. Inflammation boosts bacteriophage transfer between Salmonella spp.
    Science (2017)
  4. Diard, M. et al. Rationally designed oral vaccines can set an evolutionary trap for Salmonella Typhimurium. 
    BioRxiv (2019)
  5. Bakkeren, E. et al. Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut.
    Nature (2019)
  6. Brugiroux, S. et al. Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium.
    Nature Microbiology (2016)