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PhD Student Position (100%)

PhD student in Structural Biology of Abelson kinase (100%)

Abstract
A PhD student position is available in the group of Prof. Stephan Grzesiek at the Biozentrum Basel. Our aim is to apply and develop modern NMR methods in combination with other biophysical techniques to decipher the functional mechanisms of disease-relevant proteins at a fundamental level [1–10].

Description
Deregulation of Abelson kinase (Abl) due to an oncogenic chromosome translocation is the cause for chronic myelogeneous leukemia (CML). You will be involved in a project that aims to describe Abl’s regulation, oncogenic disregulation, and reaction to cancer drugs at atomic resolution using a combination of NMR and single-molecule Förster resonance energy transfer (FRET). For our previous work on this topic see [2,7,11–13].

The technical equipment includes state-of-the art 900 MHz and 600 MHz high-resolution spectrometers with cryo and magic angle spinning probes, single-molecule FRET, as well as many other biophysical technologies and a protein expression lab. The Biozentrum offers a stimulating interdisciplinary environment and in-house availability of all methods of modern structural biology. The PhD training will include formal education within the Biozentrum’s graduate teaching program.

For further information please visit http://www.biozentrum.unibas.ch/grzesiek

Key words: Abelson kinase, cancer, biophysics, pharmacology, single-molecule FRET, NMR

References:
[1]    L. Nisius, S. Grzesiek, Nature chemistry, 2012, 4, 711.
[2]    L. Skora et al., Proceedings of the National Academy of Sciences, 2013, 110, E4437.
[3]    N. Vajpai et al., Proceedings Of The National Academy Of Sciences Of The United States Of America, 2013, 110, E368.
[4]    J. Habazettl et al., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111, E5498.
[5]    M. Aznauryan et al., Proceedings Of The National Academy Of Sciences Of The United States Of America, 2016, 113, E5389.
[6]    S. Isogai et al., Nature, 2016, 530, 237.
[7]    R. Sonti et al., Journal of the American Chemical Society, 2018, 140, 1863.
[8]    L.A. Abiko, A. Grahl, S. Grzesiek, Journal of the American Chemical Society, 2019, 141, 16663.
[9]    A. Grahl et al., Nature Communications, 2020, 11, 2216.
[10]    P. Isaikina et al., bioRxiv, 2020, 2020.11.27.401117.
[11]    N. Vajpai et al., The Journal of biological chemistry, 2008, 283, 18292.
[12]    N. Vajpai et al., Biomolecular NMR assignments, 2008, 2, 41.
[13]    J. Zhang et al., Nature, 2010, 463, 501.

Requirements
Candidates must have a master degree in biochemistry, physical chemistry, physics or a related scientific discipline at the time of the PhD start. They should have experience in one or several of the following areas: molecular biology or cell biology with a background in protein structure, biomolecular fluorescence spectroscopy, or macromolecular NMR.

Applications
Applications should include cover letter, CV, diplomas, and contact information of two references. Applications and informal queries about the lab and research projects should be directed by email to Prof. Stephan Grzesiek.


Contact
Prof. Stephan Grzesiek
Biozentrum, University of Basel
Klingelbergstrasse 70
CH-4056 Basel, Switzerland

e-mail: stephan.grzesiek-at-unibas.ch
www.biozentrum.unibas.ch/grzesiek