Prof. Dr. Michael N. Hall

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 512 Phone: +41 61 207 21 50
Email: m.hall-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Brigitte Olufsen
Biozentrum, Room 510
Phone: +41 61 207 21 45
Fax: +41 61 207 21 48
Email: brigitte.olufsen-at-unibas.ch

Video

2017 Albert Lasker Basic Medical Research Award
Canada Gairdner International Award 2015.
Weltenreise

News

Liver cancer: Lipid synthesis promotes tumor formation

Lipid, also known as fat, is an optimal energy source and an important cell...more

Lasker Award for Michael N. Hall

Professor Michael N. Hall from the Biozentrum of the University of Basel...more

Michael N. Hall awarded Cancer Research Prize

On February 8th, 2017, the American National Foundation for Cancer Research...more

Research group Michael N. Hall

TOR signaling and the control of cell growth

Understanding the molecular mechanisms that control growth and metabolism in health and disease may reveal new therapeutic strategies for a wide variety of disorders.

Architecture of human mTOR complex 1

Cell growth is a highly regulated, plastic process controlled by TOR-dependent pathways in response to nutrients, growth factors and energy.

TOR is a major controller of cell growth

TOR (Target of Rapamycin) is a conserved protein kinase that controls a wide range of metabolic processes. More importantly, TOR is a central controller of cell growth that plays a key role in development and ageing. TOR is implicated in many disorders including cancer, cardiovascular disease, diabetes, and obesity. The aim of our research is to elucidate the mechanisms by which TOR is regulated and in turn how it controls its many processes in both health and disease.

Investigating TOR signaling in human tumors

We study TOR signaling and growth control in the yeast Saccharomyces cerevisiae, in mammalian cells, in mice and in human tumors using biochemical, genetic and cell biological approaches. The work with human tumors is a translational research project that relies on close collaborations with clinicians.

New therapeutic strategies

Cell division, growth and death are the most fundamental features of life. Our studies contribute to understanding the important process of cell growth. Understanding mammalian TOR (mTOR) signaling and how it is dysregulated in disease may reveal new therapeutic strategies for a wide variety of disorders.