| ORCID | 0000-0002-2998-0757 |
| Google Scholar | Google Scholar |
| Nationality: | Swiss |
| Positions: | |
| Since 2023 | Principal Investigator, Institute of Human Biology, F. Hoffmann-La Roche Ltd, Basel, Switzerland |
| Since 1992 | Professor, Biozentrum |
| 2013 – 2016 | Vice-Director, Biozentrum |
| 2002 – 2009 | Vice-Director, Biozentrum |
| 2002 – 2008 | Chairman, Division of Biochemistry |
| 1995 – 1998 | Chairman, Division of Biochemistry |
| 1987 – 1992 | Assistant Professor, Division of Biochemistry, Biozentrum, University of Basel, Basel, Switzerland |
| 1984 – 1987 | Asst. Research Biochemist/Principal Investigator, Department of Biochemistry & Biophysics, University of California, San Francisco, California, USA |
| 1981 – 1984 | Helen Hay Whitney Fellow, Department of Biochemistry & Biophysics, University of California, San Francisco, California, USA |
| 1981 – 1981 | Association pour le Développement de l'Institut Pasteur (ADIP) Fellow, Unité de Génétique Moléculaire, Institut Pasteur, Paris, France |
| 1979 – 1981 | Harvard University Traveling Scholar NCI, Cancer Biology Program, Frederick Cancer Research Center, Frederick, Maryland |
| 1976 – 1979 | NIH Training Grant Fellow, National Research Service Award, Department of Microbiology & Molecular Genetics, Harvard Medical School, Boston, Massachusetts |
| 1975 – 1976 | Research Assistant with Marshall Edgell and Clyde Hutchison, Department of Bacteriology & Immunology, University of North Carolina, Chapel Hill, North Carolina |
| Education: | |
| 1981 – 1984 | Postdoctoral Fellow, University of California, San Francisco, Department of Biochemistry & Biophysics (Ira Herskowitz) |
| 1981 | Ph.D., Harvard University, Department of Microbiology & Molecular Genetics (Thomas J. Silhavy) |
| 1976 | B.S. with Honors, University of North Carolina, Chapel Hill, Department of Zoology |
| 1971 | High School, St. Mark's School, Southborough, Massachusetts |
| Awards & Honors: |
| 2025 | Academia Europaea, elected |
| 2025 | Mike Hogg Award, UT MD Anderson Cancer Center, Houston |
| 2024 | FEBS National Lecture Award, Greece |
| 2024 | Balzan Prize for Biological Mechanisms of Aging |
| 2024 | Helis Foundation Lifetime Achievement Award |
| 2023 | Grande Médaille, French Academy of Sciences |
| 2023 | George E. Palade Memorial Lecture, Cell Biology at the Yale School of Medicine |
| 2023 | Distinguished Visiting Professorship, Duke-NUS Medical School, Singapore |
| 2022 | Axel Ullrich Medal, Max-Planck-Institute for Biochemistry, Martinsried, Germany |
| 2021 | Vallee Visiting Professorship Award, The Bert L. & N. Kuggie Vallee Foundation |
| 2021 | Prix Mondial Nessim Habif, University of Geneva |
| 2020 | Sjöberg Prize, The Royal Swedish Academy of Sciences, Sweden (with D. M. Sabatini) |
| 2020 | Doctor honoris causa, The Hebrew University of Jerusalem, Israel (conferred 2024) |
| 2020 | Honorary Member, Japanese Biochemical Society |
| 2019 | Frontiers of Knowledge Award in Biomedicine, BBVA Foundation, Spain (with D. M. Sabatini) |
| 2019 | HFSP Nakasone Award |
| 2019 | Verna and Marrs McLean Lecture, Baylor College of Medicine, USA |
| 2019 | Howard Taylor Ricketts Award, University of Chicago, USA |
| 2019 | Brupbacher Prize for Cancer Research, C. R. Brupbacher Foundation |
| 2018 | Bruce Merrifield Distinguished Lecture, The Rockefeller University, USA |
| 2018 | H. M. Hanna Lecture, Case Western Reserve University, USA |
| 2018 | King Lecture, Clare Hall, University of Cambridge, UK |
| 2018 | Genome Valley Excellence Award, BioAsia, Hyderabad, India |
| 2017 | Lelio Orci Award for Advances in Cell Biology, University of Geneva/Life Sciences Switzerland |
| 2017 | Albert Lasker Basic Medical Research Award, Albert and Mary Lasker Foundation |
| 2017 | Szent-Györgyi Prize for Progress in Cancer Research, National Foundation for Cancer Research (NFCR) |
| 2016 | Distinguished Investigator, Instituto de Biomedicina de Sevilla (IBiS), Spain |
| 2016 | Debrecen Award for Molecular Medicine, University of Debrecen, Hungary |
| 2016 | Doctor honoris causa, University of Geneva |
| 2016 | Thomson Reuters Citation Laureate |
| 2016 | Benning Lecture, University of Utah, USA |
| 2015 | Canada Gairdner International Award for Biomedical Research, Gairdner Foundation |
| 2015 | UCSF Alumni Excellence Award |
| 2014 | National Academy of Sciences USA, elected |
| 2014 | Breakthrough Prize in Life Sciences |
| 2014 | Sir Hans Krebs Medal, Federation of European Biochemical Societies (FEBS) |
| 2014 – 2020 | ERC Synergy Grant, Corresponding Principal Investigator |
| 2014 | University Visiting Professorship (Marie Amelia & Mathew Heller, Joseph & Rebecca Weiss Visiting Chair of Medicine), The Hebrew University, Jerusalem |
| 2013 | Christian de Duve Lecture (Inaugural), The de Duve Institute and Université Catholique de Louvain, Brussels, Belgium |
| 2013 | Jesus Montoliu Lecture, The Biomedical Research Institute of Lleida, Spain |
| 2013 | Swiss Academy of Medical Sciences, elected |
| 2012 | Marcel Benoist Prize for Sciences or Humanities, Marcel-Benoist-Stiftung |
| 2012 | EMBO Lecture, Oslo, Norway |
| 2011 | Allan C. Wilson Lectures, University of California, Berkeley, USA |
| 2010 | Mendel Lecture, Czech Academy of Arts and Sciences and Masaryk University, Brno, Czech Republic |
| 2009 | Fellow of the American Association for the Advancement of Science (AAAS), elected |
| 2009 | Runnström Lecture, University of Stockholm |
| 2009 | Louis-Jeantet Prize for Medicine, Fondation Louis-Jeantet |
| 2008 – 2016 | Swiss National Science Foundation Research Council |
| 2004 | Susan Swerling Lecture, Harvard Medical School |
| 2003 | Cloëtta Prize for Biomedical Research, Prof. Dr. Max Cloëtta Foundation |
| 1995 | Member of the European Molecular Biology Organization (EMBO), elected |
| 1982 | Litton Advanced Technology Achievement Award |
| 1981 – 1984 | Helen Hay Whitney Fellowship |
| 1981 | ADIP Fellowship, Institut Pasteur, France |
| 1976 – 1979 | NIH Training Grant Fellowship, National Research Service Award, USA |
| Selected Memberships: |
| Since 2024 | Scientific Advisory Board, Institute of Oncology Research (IOR), Bellinzona, Switzerland |
| Since 2022 | Co-Founder and Board of Directors (Chair), Torqur AG |
| Since 2022 | Cancer Grand Challenges Scientific Committee, Cancer Research UK and NCI |
| 2022 – 2023 | Management Board, Basel Life Sciences Association (President, 2022-2023) |
| Since 2022 | Advisory Board, Faculty of Sciences, University of Lisbon, Portugal |
| Since 2021 | Board of Directors, ISREC Foundation |
| 2021 | EMBO Director ad interim |
| 2021 – 2023 | Institut Pasteur Director Search Committee |
| 2021 – 2025 | Scientific Advisory Board, Center for Genomic Regulation (CRG), Barcelona, Spain |
| Since 2021 | Dr. Paul Janssen Award Selection Committee |
| 2020 – 2026 | Scientific Advisory Board, Max-Planck-Institute for Biology of Ageing, Cologne, Germany |
| Since 2020 | Scientific Advisory Board, Cure Overgrowth Syndromes (COSY), Paris, France |
| 2020 – 2024 | Scientific Advisory Committee (Chair), Center for Microbes, Development and Health (CMDH), Institut Pasteur of Shanghai |
| 2020 | VIB Review Board (Co-Chair), Flanders, Belgium |
| 2020 – 2021 | EMBO Director Search Committee (Chair) |
| Since 2020 | Shaw Prize Selection Committee |
| 2020 – 2023 | Scientific Advisory Board (Chair), FoRx Therapeutics AG |
| 2020 | Scientific Advisory Board, Vaderis Therapeutics |
| Since 2020 | Albert Lasker Medical Research Awards Jury |
| Since 2019 | Board of Directors, Swiss Rockets AG |
| Since 2018 | Associate, Clare Hall, Cambridge University, UK |
| Since 2018 | International Advisory Board, IUBMB/FAOBMB/ComBio meeting 2024, Melbourne, Australia |
| Since 2018 | Selection Committee (Chair in 2018), Szent-Györgyi Prize, National Foundation for Cancer Research (NFCR) |
| 2017 – 2020 | Editorial Board, Current Opinion in Cell Biology |
| Since 2017 | American Society for Biochemistry and Molecular Biology (ASBMB) |
| Since 2017 | Scientific Advisory Board, Swiss Institute for Basic Cancer Research (ISREC) Foundation |
| 2017 – 2022 | European Molecular Biology Organization (EMBO) Council (Chair, 2021-2022) |
| 2017 – 2027 | Board of Trustees, Marcel Benoist Foundation, Bern |
| Since 2016 | EMBO-Basel Life Organizing Committee |
| 2016 – 2022 | EALS Management Board |
| 2016 – 2022 | Executive Board, European Assoc. for Life Sciences (EALS), President (2019-2022) |
| Since 2016 | International Scientific Advisory Board, Cambridge Institute for Medical Research |
| 2016 – 2018 | Executive Board, Personalized Health Basel |
| 2016 – 2019 | European Research Council (ERC) Advanced Grants evaluation panel |
| Since 2015 | American Association for Cancer Research (AACR) |
| 2015 – 2016 | Editorial Board, ScienceMatters |
| 2015 – 2019 | Scientific Advisory Board, Navitor Pharmaceuticals, Inc. |
| 2014 | External Review Committee, Okinawa Institute of Science and Technology (OIST), Japan |
| Since 2014 | Scientific Advisory Board, MRC-Laboratory of Molecular Cell Biology, London |
| Since 2014 | Board of Trustees, Louis-Jeantet Foundation, Geneva |
| 2014 – 2018 | Scientific Council, de Duve Institute, Brussels, Belgium |
| Since 2014 | Selection Committee, Breakthrough Prize in Life Sciences Foundation |
| 2012 – 2020 | Scientific Advisory Board, PIQUR Therapeutics |
| 2012 – 2017 | Scientific Advisory Board, Max-Planck Institute for Biochemistry, Martinsried, Germany |
| 2012 – 2015 | EMBO Young Investigator Programme (YIP) Selection Committee, Heidelberg, Germany |
| 2011 – 2025 | Scientific Advisory Board (Chair, 2023-), Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Germany |
| 2011 – 2015 | Review Panel, National Center of Research (NCCR) in Chemical Biology, Switzerland |
| Since 2011 | Editorial Board, The EMBO Journal |
| 2011 | Expert Panel, External Research Assessment, Karolinska Institute, Stockholm |
| 2011 | Guest-Editor, Current Opinions in Cell Biology, issue on Cell Division, Growth and Death |
| 2011 – 2025 | Scientific Committee, Louis-Jeantet Foundation, Geneva |
| Since 2010 | Scientific Advisory Board, Faculty of Medicine, University of Geneva (Chair, 2020-) |
| 2009 – 2010 | American Chemical Society |
| Since 2009 | Editorial Board, Journal of Molecular Cell Biology |
| Since 2009 | Editorial Board, Aging |
| 2009 – 2017 | Director, Basel Signaling Alliance |
| 2008 – 2018 | SNSF Ambizione Grants evaluation panel |
| 2008 – 2012 | Review Panel, National Center of Research (NCCR) in Structural Biology, Switzerland |
| 2008 – 2013 | Editorial Board, FEBS Journal |
| 2008 | External Review Committee, Okinawa Institute of Science and Technology (OIST), Japan |
| Since 2007 | European Association for Cancer Research |
| 2007 – 2009 | Editor-in-Chief, International Journal of Molecular Sciences (open access journal) |
| 2007 – 2011 | Editorial Board, The Open Cell and Developmental Biology Journal |
| 2007 | Scientific Advisory Board, Longevity Pharmaceuticals LLC |
| 2007 – 2012 | Editorial Board, Autophagy |
| 2006 – 2008 | Editorial Board, Current BioData Lipid Signalling |
| Since 2006 | Editorial Board, Cell Cycle |
| 2006 | Chair, Biosciences Panel, Academy of Finland |
| 2004 | SystemsX (Swiss System Biology) Strategy Committee |
| 2004 – 2006 | Executive Committee, ETH Inst. for Biosystems |
| 2002 | Ramón y Cajal Programme, Fellowship Committee, Madrid, Spain |
| Since 2002 | American Society for Cell Biology |
| 2001 – 2008 | Faculty of 1000 |
| 1998 – 2000 | Commission de Spécialistes, Université de Bourgogne, Dijon, France |
| Since 1988 | Swiss Biochemical Society |
| Since 1986 | Genetics Society of America |
| Since 1981 | American Association for the Advancement of Science |
| 1979 – 1995 | American Society for Microbiology |
| Miscellaneous: | |
| 2025 | EMBO Global Activities Working Group |
| 2025 | Lola and John Grace Distinguished Lecture in Cancer Research, EPFL, Switzerland |
| 2025 | EMBL Director General Search Committee |
| 2024 | Craig Jordan Lecture, MRC Weatherall Institute, Oxford, UK |
| 2024 | Keynote Lecture, FASEB Conference, Hippo Pathway in Biology and Disease, Florida, USA |
| 2024 | Co-organizer, 2024 Louis-Jeantet Symposium on Diabetes and Metabolism, Geneva, Switzerland |
| 2024 | Crick Lecture, Francis Crick Institute, London |
| 2024 | EMBO Global Lecturer, India |
| 2023 | Keynote Lecture, iMed Conference, Lisbon, Portugal |
| 2023 | Keynote Lecture, Groningen-Jena Aging Meeting Groningen, The Netherlands |
| 2023 | Keynote Lecture, European Association for Cancer Research (EACR), Torino, Italy |
| 2023 | Keynote Lecture, International Student Congress of Medical Sciences (ISCOMS), Groningen, The Netherlands |
| 2022 | Keynote Lecture, CATCAT Symposium, Barcelona, Spain |
| 2022 | Charles R. Cantor Lecture (Inaugural), Department of Genetics and Development, Columbia University, NYC |
| 2022 | Keynote Lecture, Copenhagen Bioscience Conference: Metabolism in Action, Denmark |
| 2022 | Keynote Lecture, 34th European Congress of Pathology, Basel, Switzerland |
| 2021 | Keynote Lecture, EMBO Workshop on TOR in Photosynthetic Organisms, Portugal/virtual |
| 2021 | Keynote Lecture, 11th International Symposium on AMPK, Evian-les-Bains, France |
| 2021 | Keynote Lecture, EMBO Workshop on Cell Size and Growth Regulation, Tel Aviv, Israel |
| 2020 | Public Keynote Lecture, NYU Abu Dhabi, United Arab Emirates |
| 2019 | EMBO Global Lecturer, Chile |
| 2019 | Keynote Lecture, Frontiers in Cancer Science, Singapore |
| 2019 | Keynote Lecture, Areces Foundation Meeting, Madrid, Spain |
| 2019 | Keynote Lecture, Personalized Oncology Conference, Basel, Switzerland |
| 2019 | Keynote Lecture, 130 Years of Institut Pasteur, Paris, France |
| 2019 | Howard Taylor Ricketts Lecture, University of Chicago |
| 2019 | Co-organizer, EMBO at Basel Life Conference: Next-generation Molecular Medicine, Basel, Switzerland |
| 2018 | Lecturer, Course on Signal Transduction, Israel Institute for Advanced Studies, The Hebrew University, Jerusalem |
| 2018 | Keynote Address, Toyama Symposium, Japan |
| 2018 | Keynote Lecture, Roche Continents, Salzburg, Austria |
| 2018 | Keynote Lecture, TOR de France, Nice, France |
| 2018 | Keynote Address, BioAsia 2018, Hyderabad, India |
| 2018 | EMBL Distinguished Visitor Lecture, Heidelberg, Germany |
| 2018 | Co-organizer, EMBO at Basel Life Conference: Molecules in Biology and Medicine, Basel, Switzerland |
| 2017 | Plenary Lecture, ASCB-EMBO Congress, Philadelphia, USA |
| 2017 | ASBMB Grimwade Keynote Lecture, ComBio, Adelaide, Australia |
| 2017 | Keynote Lecture, Gordon Research Conference, Integrative Biology of Aging, Switzerland |
| 2017 | Karl Wilhelm von Kupffer Lecture, The International Liver Congress, Amsterdam |
| 2017 | Lola and John Grace Distinguished Lecture in Cancer Research, EPFL |
| 2016 | Keynote Lecture, 9th International Symposium on AMPK, Xiamen, China |
| 2015 | Keynote Lecture, 40th European Symposium on Hormones and Cell Regulation, Mont Sainte-Odile, France |
| 2015 | Keynote Lecture, International Tuberous Sclerosis Complex Research Conference, Windsor, England |
| 2015 | Instructor, FEBS advanced course on Signal Transduction and Cancer, Spetses, Greece |
| 2015 | Honors Program Lecture, New York University School of Medicine, NYC |
| 2015 | Co-organizer, International Abcam Conference: PI3K-like Protein Kinases, Milan, Italy |
| 2014 | Keynote Lecture, EMBO/EMBL Symposium: Frontiers in Metabolism, Heidelberg, Germany |
| 2014 | Sir Hans Krebs Lecture, FEBS-EMBO Congress, Paris, France |
| 2014 | Roche Commissions, research as architecture, architecture as research, with Jacques Herzog |
| 2014 | Keynote Lecture, FASEB Research Conference, Lipids and Lipid Regulated Kinases in Cancer, Steamboat Springs, USA |
| 2014 | Co-organizer, International Symposium: Targeting the Kinome III, Basel, Switzerland |
| 2014 | Keynote Lecture, Israeli Society for Cancer Research, Haifa, Israel |
| 2013 | Keynote Lecture, EMBO workshop: Mechanisms of Muscle Growth, Ascona, Switzerland |
| 2013 | Instructor, FEBS-EACR advanced course on Signal Transduction, Spetses, Greece |
| 2012 | Inaugural Lecture, Instituto de Biología Funcional y Genómica, Salamanca, Spain |
| 2012 | Keynote Lecture, Symposium of the Zürich Center for Integrative Human Physiology |
| 2012 | Co-organizer, 2012 Louis-Jeantet Symposium, Geneva, Switzerland |
| 2012 | Co-organizer, Les Treilles Conference: Growth Regulation by the TOR Pathway, France |
| 2012 | Chair, Cell Metabolism and Cell Homeostasis Symposium, German Society for Cell Biology, Dresden, Germany |
| 2012 | Plenary Lecture, International Symposium on Lipid and Membrane Biology, Graz, Austria |
| 2011 | Keynote Lecture, The TOR Kinase Signaling Pathway in Plants, Versailles, France |
| 2011 | Plenary Lecture, NCRI Cancer Conference, Liverpool, England |
| 2011 | Co-organizer, International Symposium: TOR, PI3K and Akt - 20 years on, Basel, Switzerland |
| 2011 | Lecturer, Consorzio per il Centro di Biomedicina Moleculare (CBM) Summer School, Trieste, Italy |
| 2011 | "Cell Signalling" Lecture, Spanish Society of Biochemistry and Molecular Biology, Barcelona, Spain |
| 2010 | Co-chair, ASCB Minisymposium: Cell Growth and Cell Cycle, Philadelphia, USA |
| 2010 | Keynote Lecture, Workshop: TOR, Caloric Restriction and Anabolism in Aging, Split, Croatia |
| 2010 | Keynote Lecture, Levures, Modèles et Outils IX Symposium, Strasbourg, France |
| 2010 | Lecturer, Palmse Mois Summer School in Molecular Biology, Estonia |
| 2010 | Keynote Lecture, Aging and TOR Signaling Symposium, University of Michigan |
| 2009 | Keynote Lecture, Marie Curie RTN Meeting, Berlin |
| 2009 | Co-chair, EMBO Meeting Workshop: TOR Signalling, Amsterdam |
| 2009 | Keynote Lecture, The EMBO Meeting, Amsterdam, Netherlands |
| 2008 | Co-organizer, Les Treilles Conference: Cell Growth and the TOR Pathway, France |
| 2007 | Keynote Lecture, Symposium of the Zürich Center for Integrative Human Physiology |
| 2007 | Instructor, FEBS-EMBO advanced course on Signal Transduction, Spetses, Greece |
| 2007 | Instructor, FEBS course on Yeast Systems Biology, Göteborg, Sweden |
| 2006 | Distinguished Lecture, Beatson Institute, Glasgow, Scotland |
| 2006 | Chair, Biosciences Panel, Academy of Finland |
| 2005 | Co-organizer, Les Treilles Conference: Cell Size and Shape, France |
| 2004 | Expert witness, Johnson & Johnson |
| 2003 | Consultant, MyoContract Ltd. |
| 2002 | Master Class Lecturer, Utrecht, Netherlands |
| 2002 | Keynote Lecture, MRC Molecular Physiology meeting, Dundee, Scotland |
| 2001 | Co-organizer, Les Treilles Conference: TOR and Control of Cell Growth, France |
| 2000 | External Reviewer of the Medical Research Council (MRC), England |
| 2000 | Franqui Prize Jury, Belgium |
| 1992 | Co-organizer, EMBO course on Molecular Genetics of Yeast |
| 1989 | Venia Docendi, University of Basel |
| 1989 | Co-organizer, Swiss Commission for Molecular Biology (SKMB) course on Molecular Genetics of Yeast |
| 1989 – 1990 | Consultant, Sandoz (now Novartis) |
| 1987 | Cuban Academy of Science Invited Lecturer, Havana, Cuba |
| 1985 – 1987 | Consultant, CODON |
