Structural dynamics of ordered and disordered systems D2: Biophysics of Molecules and Cells I – 13160 (2 hrs/week; 2 CP; Fall 2028) Roderick Lim , Sebastian Hiller "Structural dynamics of ordered and disordered systems" -…
Pseudomonas aeruginosa: Persistence Beyond Antibiotic Resistance The persistence of Pseudomonas aeruginosa in chronic infections extends beyond the issue of antibiotic resistance. A critical, yet unresolved question is why…
TisB-induced phenotypic heterogeneity and dormancy help E. coli to survive ofloxacin treatment TisB is a small peptide encoded by the istR1/tisB type I toxin-antitoxin system in E. coli. Expression of tisB is under the…
In recent years, the growing threat of antimicrobial resistance has become widely recognized. However, much less is known about drug-tolerant pathogens, which also complicate the treatment of bacterial infections. These…
Diatoms are too small to see with the naked eye, yet they are one of the most productive algae species in the ocean and play an important role in the global carbon cycle. Using photosynthesis, they absorb large amounts of…
Structural Biology of Bacterial Cell Division Cell division in the vast majority of bacteria is driven by the synthesis of new cell wall peptidoglycan and is catalysed by the divisome. Central to the divisome is the…
Nanoscale tracking of molecules and ions at biointerfaces: from individual diffusion to correlative group effects Biological membranes are dynamical entities that can rapidly adjust their composition and biophysical…
Unveiling Biofilm Microbiomes and Spatial Interactions in the Human Oral Niche The human oral environment harbors one of the most diverse microbiomes, with microbial constituents that dynamically interact with hard and soft…
Temperature-controlled alternative splicing: From global analysis and mechanistic insights to translational research In previous studies, we have characterized the impact of subtle changes in (human) core body temperature on…
A RNA perspective of functional genomics Only 2% of the human genome consists of protein-coding genes. The remaining 98% is non-coding and thought to encode the regulatory information for gene expression. Interpreting this…
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