D2: Molecular Biophysics I – 13160
(2 hrs/week; 2 CP; Spring 2025)
Stephan Grzesiek, Rod Lim, Dmitry Veprintsev
Biophysics tackles biological questions by the quantitative analysis of biomolecules and their interactions. The quantitative connection of structure, dynamics and energetics establishes the fundamental link between molecular mechanisms and cellular functionality. With a broad range of topics from single molecule studies to systems biology analyses, this course (spread over two parts) offers life-scientists insight into how contemporary biophysical methodologies address questions and resolve problems at the cutting edge of biology. Individual lectures will cover advanced optical spectroscopy and super-resolution techniques, analytical ultracentrifugation, mass spectrometry, nuclear magnetic resonance, electron paramagnetic resonance, x-ray crystallography, cryo-electron microscopy, surface plasmon resonance, atomic force microscopy and spectroscopy, optical/magnetic tweezers, micro/nanofluidic approaches and other methods.
The two parts of the lecture series D2 and D5 will consist of different selections from these topics, such that they can be attended independently.