Type I and III Interferons (IFNs) are part of the arsenal of immune mediators produced by innate immune cells upon detection of pathogens. This presentation will examine the interplay between enteric bacterial pathogens and IFNs. We will discuss how pathogenic inhibition of IFN signaling pathways by Shigella favours bacterial intracellular replication infection and colonisation of the murine gut. This work reveals novel roles of these IFN families in bacterial infection, which will be further examined in the context of Salmonella pathogenesis.