Prof. Dr. Richard Neher

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 677A Phone: +41 61 207 58 34
Email: richard.neher-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Nadine Iberl
Biozentrum, Room 709
Phone: +41 61 207 20 66
Fax: +41 61 207 20 78
Email: nadine.iberl-at-unibas.ch

News

Richard Neher wins the Open Science Prize

Prof. Richard Neher from the Biozentrum of the University of Basel is the joint...more

New Associate Professor appointed to the Biozentrum

The University Council has appointed Richard Neher as the new Associate...more

Research group Richard Neher

Evolution of viruses and bacteria

We study how bacteria and viruses change in order to uncover general principles of evolution.

Reconstructed phylogenetic tree and geographical spread of influenza viruses (nextflu.org).

Each year Switzerland experiences an influenza outbreak. Despite best efforts, the influenza vaccine sometimes offers only limited protection. The reason for this is that viruses and other pathogens are constantly changing in response to the pressure of the immune system or drug treatments and thus new strains emerge within a very short time.

 

Evolution at the molecular level

Our goal is to understand how evolution works at the molecular level and how organisms adapt to changing conditions through random mutations and recombination. Pathogens, such as the influenza virus, HIV and also bacteria, provide excellent model systems for studying the processes of evolution, as these organisms change rapidly and their biology is well understood.

New algorithms to analyze evolutionary dynamics

Our group applies modern sequencing techniques to decipher the genome of thousands of HIV particles and develops new algorithms to elucidate the interactions between HIV and the immune system from these data.  We combine methods from bioinformatics, population genetics, and statistical physics.

Predicting the evolution of pathogens

Understanding the processes of evolution and adaptation is important for our efforts to control the spread of infectious diseases. For example, we have developed a method which can predict the evolution of influenza viruses based on their phylogenetic tree (nextflu.org).  Such predictions can help to ensure that the seasonal influenza vaccine matches the circulating viruses.