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Engineered T cells promote long-term organ transplant acceptance

When someone is confronted with ‘foreign’ material, be it viruses, bacteria, fungi, but also donor organs following transplantation, immune cells called T cells come into action to inactivate and destroy the ”foreign”…


Survival trick: Pathogen taps iron source in immune cells

Our body keeps bacterial pathogens under control by restricting their access to essential nutrients such as iron. Iron is crucial for all living organisms. When bacteria are deprived of iron, they stop growing and…


How bacteria reinforce their protective shield against stress

When infecting a host, pathogens not only need to evade the immune defense but also to survive diverse living conditions, such as the acidic conditions in the stomach or the salty intestinal environment. Gram negative…


Why antibiotics can fail even against non-resistant bacteria

In certain infectious diseases, antibiotics are less effective than expected, as seen in infections caused by Salmonella bacteria, which can lead to illnesses such as typhoid fever. For many years, researchers believed that…


An enemy within: Pathogens hide in tissue

Infections such as tuberculosis or typhoid fever are caused by bacteria and can usually be treated well with antibiotics, at least as long as the bacteria are not resistant. However, full eradication of the bacteria cannot…