Cholesterol-lowering agents, antihypertensives or malaria medications, cancer drugs and antibiotics - many of our current drugs are based on natural products. Bacteria and fungi actually produce these chemical substances in…
Nuclear magnetic resonance spectroscopy of biomolecules We apply and develop high-resolution Nuclear Magnetic Resonance (NMR) methods to elucidate structure, function, and dynamics of biological macromolecules. The…
Since his time as a postdoctoral fellow at Harvard Medical School in Boston, Marek Basler has been fascinated by a tiny bacterial injection apparatus, the so-called type 6 secretion system (T6SS). This nanomachine works like…
From uncharted sequence space to de novo proteins From uncharted sequence space to de novo proteins Biological proteins form mostly tightly clustered families in the pool of possible combinations of canonical amino acids.…
With the revolutionary CRISPR/Cas technology, the DNA of living organisms can be precisely altered. Using a guide RNA that recognizes a specific DNA sequence, Cas9 protein is recruited to that sequence and cuts the DNA. This…
Breast cancer is by far the most frequent type of cancer affecting women and a leading cause of death, despite advances in its detection and treatment. There are different forms of breast cancer and the causes are just as…
In the course of evolution, the human body has developed diverse strategies to protect itself from harmful substances. In the intestine, the placenta and also in the blood-brain barrier are tiny transport proteins, which…
Support for Structural Bioinformatics Computational structural biology is an increasingly important multidisciplinary field that uses advanced models and computational techniques to understand and solve complex problems…
Antibiotics are still the treatment of choice in fighting bacterial infections. However, due to their extensive and sometimes improper use in medicine and livestock farming, resistant pathogens are increasingly emerging,…
Prof. Ben Engel on recognizing our connection with the environment Ben Engel about his childhood in California, his love of nature, and the importance of scientific communication. You grew up in California - how would you…
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