Instruments The instruments shown below are available in the Biophysics Facility (BF) of the Biozentrum and can be booked and used by all members of the University of Basel, following training by BF staff. The instruments…
Electron Tomography Application To obtain a 3D model for objects that are too thick or vary too much in size and shape for single particle electron microscopy (≥ 1 micrometer thick), e.g., small cells, cellular organelles…
TFS Titan Krios G4 TEM Configuration The Titan Krios G4 from Thermo Fisher Scientific is a high-end transmission cryo-electron microscope designed for ultimate performance and productivity across a wide range of Life Science…
Applications Single particle analysis is generally used to determine the 3D structure of globular proteins and protein complexes at high resolution. Method Grids holding purified protein samples are plunge-frozen in liquid…
Thermo Fisher Scientific Aquilos 2 Cryo-FIB Configuration The Aquilos 2 cryo-FIB is the latest generation cryo-DualBeam instrument with enhanced anti-contamination hardware for improved cryo-sample protection and minimal ice…
Protein Filaments Applications To determine the structure of filaments and their subunits at high resolution. Method Grids holding purified filament samples are plunge-frozen in liquid ethane and imaged. The 3D structure(s)…
Cryo-FIB milling Application A specialized technique for TEM specimen preparation to mill a bulk specimen with focused gallium (Ga) ions. The target region of the specimen can be selectively thinned down to a desired shape…
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