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Overview

SEAL Therapeutics AG: Gene therapy for muscular dystrophy The Biozentrum spin-off develops an innovative gene therapy to treat congenital muscular dystrophy. Cross-section through treated LAMA2 MD muscle with individual…


LAMA2 MD

LAMA2-related muscular dystrophy (LAMA2 MD; also called MDC1A) Congenital muscular dystrophies (CMDs) are a group of genetic muscle diseases with onset at birth or very early infancy. The more than 30 known forms of these…


SEAL Technology

SEAL Technology The innovative gene therapy approach (called SEAL technology), developed by Prof. Markus Rüegg and Prof. Peter Yurchenco and their teams over the past 20 years, overcomes the lack of laminin-α2 in muscle…


Team

The Team Prof. Markus Rüegg, PhD, CEO and Member of the Board Training in biochemistry and neurosciences Proven track record in neuromuscular research Full Professor for neurobiology Thomas Meier, PhD Chairman of the Board…


Contact

SEAL Therapeutics AG c/o Markus A. Rüegg, CEO Biozentrum, University of Basel Spitalstrasse 41 CH-4056 Basel/Switzerland markus-a.ruegg unibas ch https://www.sealtherapeutics.com/ X: @SEAL_Tx Linkedin:…


Literature

Literature McKee KK, Yurchenco PD. Amelioration of muscle and nerve pathology of Lama2-related dystrophy by AAV9-laminin-alphaLN linker protein. JCI Insight. 2022;7(13) .


BSc in Computational Sciences

Bachelor of Science in Computational Sciences, Major in Computational Biology Developments in computer science as well as in large scale methods for data collection have changed the practice of natural sciences. The…


Obituary for Johan N. Jansonius (1932 - 2022)

The scientist passed away at the age of 89 years, on 2 January 2022, in Therwil. With him, the Biozentrum loses an outstanding structural biologist and one of its founding professors. He contributed fundamental insights into…


A springboard into research for Bachelor students

What is it like to work as a scientist? How does a research group work? And what questions do scientists face on a day-to-day basis while driving forward a scientific research project? The opportunity to get to the bottom of…


CV

CV of Prof. Dr. Richard Neher ORCID 0000-0003-2525-1407 Google Scholar Google Scholar Nationality: German Positions: Since 2025 Full Professor, Biozentrum, University of Basel, Switzerland 2017 - 2025 Associate Professor,…