Prof. Dr. Dirk Bumann

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 478 Phone: +41 61 207 23 82
Email: dirk.bumann-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Michaela Hanisch
Biozentrum, Room 408
Phone: +41 61 207 21 21
Fax: +41 61 207 21 18
Email: michaela.hanisch-at-unibas.ch

News

Immune defense without collateral damage

The research groups led by Prof. Dirk Bumann at the Biozentrum, University of...more

EMBO Membership for Mihaela Zavolan and Dirk Bumann

Prof. Mihaela Zavolan and Prof. Dirk Bumann from the Biozentrum of the...more

Long antibiotic treatments: slowly growing bacteria to blame

Whether pneumonia or sepsis – infectious diseases are becoming increasingly...more

Research group Dirk Bumann

The metabolism of pathogenic organisms as a target for intervention

Pathogenic organisms utilize complex metabolic networks to replicate within host tissues. This process is key to their disease causing potential.

Salmonella in a human host cell.

Infectious diseases are becoming more pressing health problems worldwide. Growing resistance of the pathogens increasingly restricts the effectiveness of the antibiotics in use today. At the same time, hardly any new drug substances are being discovered, which means that progressively fewer therapeutic options remain available for infectious diseases.

Metabolism in contest between host and pathogen

Metabolic processes are crucial for the replication of pathogens and the outbreak of disease in the host. At the same time, metabolic processes are also ideal targets for intervention to kill the pathogens. Using disease models of typhoid fever and diarrhea, our research group is investigating how Salmonella and Shigella obtain nutrition from their hosts, what enzymes they use to degrade these nutrients, and how they coordinate the individual activities in metabolic networks. We isolate pathogens from infected host cells, analyze their proteins, and simulate the metabolic processes in computer models.

Target for treating infectious diseases

Our goal is to gain a comprehensive understanding of metabolic activities in pathogens and, on this basis, to develop and test experimentally new therapeutic approaches to infectious diseases.