Vertebrate Development and Behavior → Schierlab Although scientific knowledge has advanced enormously in the last thirty years, we still only superficially understand how a single fertilized egg cell develops to form a…

Join us! Are you interested in becoming part of the team? Feel free to contact us anytime! We are looking for highly motivated and curious PhD students with a background in theoretical physics, computational biology, applied…

IMCF guidelines 1. General booking Rules: The user can book a microscope only after having received the appropriate introduction. The instruments can be booked up to 14 days in advance. During daily working hours (9-17h),…

Thin Sectioning Application To determine the ultrastructure of whole tissues and cells at ~2nm resolution by transmission electron microscopy (TEM). Method Tissues or cells are chemically fixed, dehydrated, embedded in resin…

Available Microscope Systems Searching for a decision tree? Clicking on the image below and you will be directed to our internal documentation that will help you to decide which system is best for your research project. If…

Image Gallery To share your scientific images taken at the IMCF in this gallery, please send your images to Alexia with a short description. The images contained within this gallery remain the copyright of the Biozentrum.…

Cell receptor dynamics and signaling G protein-coupled receptors (GPCRs) are a large family of membrane proteins crucial for cell signaling and the target of about 35 percent of all drugs. Despite that the knowledge of GPCRs…

Dr. Sheida Hadji Rasouliha Postdoc at the Imaging Core Facility Could you briefly describe your role at the Biozentrum? At the Imaging Core Facility, we are mainly responsible for teaching users the basics of light…

Cryo-FIB milling Application A specialized technique for TEM specimen preparation to mill a bulk specimen with focused gallium (Ga) ions. The target region of the specimen can be selectively thinned down to a desired shape…

Chromosomes in 3D The developmentally dynamic nucleus How are chromosomes organized within nuclei? And how does organization impact developmental events? The nucleus is very dynamic during embryogenesis, in part because…