Human Frontier Science Program: In search of conserved mRNA localization and anchoring mechanisms We have started a new international collaborative program with Prof. Chris Brown (University of Otago, Dunedin, New Zealand)…
Muscle aging Rapid advances in treating life-threatening, age-related diseases, such as cancer and cardiovascular disease, have extended human lifespan in many developed countries. However, greater longevity has meant more…
Principles of intracellular organization Correct intracellular localization of proteins and mRNA ensures cell survival. Specific localization of these molecules allows the development of multicellular organisms such as…
Publication list - curated & annotated Recent highlights Bacteria use a general danger signal to trigger biofilm formation - Nature Microbiology 2025 Mechanical properties of biofilms measured with spatial resolution -…
TOR signaling and control of cell growth Fig. 1: Architecture of human mTOR complex 1 Introduction Cell growth is highly regulated. Cells respond to nutrients or other appropriate growth stimuli by up-regulating…
Principles of intracellular organization Asymmetry is an inherent property of most cells. Proteins and mRNA have to be distributed at specific cellular locales to perform their assigned function or to be translated in a…
We study the cellular organization and regulation of metabolism by large macromolecular assemblies as well as giant microbial biosynthetic assembly lines. Our research builds on hybrid use of state-of-the-art cryo electron…
Gene expression regulatory programs Although the genetic material is more or less identical in all cells of our body, which genes are being “read” and how they are read to produce RNAs and proteins varies between cell types.…
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