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Heat stress reduces lifetime of mRNA molecules

The coronavirus pandemic and the development of the novel vaccines has brought mRNA into the public eye. mRNAs are transcripts of DNA. They serve as a template for protein production and are degraded after a certain time.…


Architecture of cellular control center mTORC2 elucidated

The protein complex mTORC2 plays a crucial role in the regulation of cellular metabolism. It stimulates, for example, the production of lipids and fatty acids, but it also controls carbohydrate metabolism. In the past,…


HFSP

Human Frontier Science Program: In search of conserved mRNA localization and anchoring mechanisms We have started a new international collaborative program with Prof. Chris Brown (University of Otago, Dunedin, New Zealand)…


How neuromuscular connections are maintained after nerve lesions

The protein complex mTORC1 promotes muscle growth and is important for the self-cleaning process of the muscle cells. The role of mTORC1 in skeletal muscle fibers in response to nerve injury has so far not been studied in…


Survival strategy of messenger RNAs during cellular sugar shortage

If a cell encounters a stress situation, whether it is due to nutrient restriction or osmotic shock, the cell reacts immediately to ensure its survival. Prof. Anne Spang’s research group at the Biozentrum of the University…


"Benchtop mesoSPIM"

Benchtop mesoSPIM (mesoscale selective plane illumination microscopy) LOCATION: Room 07.092 SPECIFICATIONS: XY-stage: motorized Software: mesosPIM-control Camera: Photometrics IRIS 14 25 mm camera sensor FOV (diagonal) 4.25…


How the key protein mTOR controls cell growth

Cells proliferate by dividing repeatedly. Each cell division produces two daughter cells, which must first grow to a certain size before they can divide, too. This requires an increased production of cell components,…


Venture Kick support for Biozentrum spin-off Aukera Therapeutics

It was only at the beginning of the year that the Biozentrum spin-off Aukera Therapeutics qualified for the BaseLaunch Accelerator program. Now the two young entrepreneurs Dr. Stefan Imseng and Dr. Dritan Liko can add…


A new layer of control in embryonic development

Genes provide the blueprint for life, determining when and where proteins are made. This process involves two key steps: transcription, from DNA to messenger mRNA (mRNA), and translation, where mRNA is decoded into proteins.…


The building in numbers

The building in numbers Height of construction 73 meters Height of Entrance Hall 13 meters Usable floor area 23’400 m 2 Volume 238’000 m 3 : 60 % above ground / 40 % below ground Rooms Laboratories 40 individually designed…