Principles of intracellular organization Asymmetry is an inherent property of most cells. Proteins and mRNA have to be distributed at specific cellular locales to perform their assigned function or to be translated in a…
Former group members Name Position Current Role Elieke Willems Kramer PhD Student 2017-2022 Charlotte Czernecki PhD Student 2017-2022 Nadia Schlauri Master Student 2021-2022 University of Basel, Switzerland Maxime Mazille…
Neuronal circuit assembly in development and disease We use a multidisciplinary approach to uncover fundamental mechanisms of neural development and plasticity. We combine advanced genetic, cell biological,…
Services & Software SWISS-MODEL A fully automated and fast protein structure homology-modelling server with the purpose of making protein modelling accessible to all life science researchers worldwide ( reference ).…
Videos Weltenreise – Vom Kosmos zur Nanowelt. Video of Prof. Anne Spang Sorting of cellular components Video of Prof. Anne Spang Life of a transport vesicle - The Vesicle Dance.
SPLICECODE - Alternative Splicing Codes for Synaptic Specificity The SPLICECODE project funded by an Advanced Grant from the European Research Council explore the hypothesis that alternative splicing is a central mechanism…
Muscular dystrophies Muscular dystrophies are rare, genetic diseases often caused by mutations in genes important for the structural stability of muscle fibers during contraction. As a consequence, affected children show…
NMJ maintenance and remodeling The neuromuscular junction (NMJ) is a chemical synapse that transmits motor neuron action potentials into muscle fiber action potentials (see Figure below). Without this connection, muscle…
Muscle aging Rapid advances in treating life-threatening, age-related diseases, such as cancer and cardiovascular disease, have extended human lifespan in many developed countries. However, greater longevity has meant more…
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