Diabetes is a medical condition in which the body is unable to keep blood sugar in a healthy range. Normally, the pancreas produces sufficient insulin to regulate the blood sugar level and maintain homeostasis. However, in…

Research projects We investigate the physiology of bacterial pathogens ( Salmonella , Pseudomonas , Staphylococcus ) in infected rodent and human tissues, focusing on single-cell behavior and potential applications for novel…

With the revolutionary CRISPR/Cas technology, the DNA of living organisms can be precisely altered. Using a guide RNA that recognizes a specific DNA sequence, Cas9 protein is recruited to that sequence and cuts the DNA. This…

After more than two years of the Covid pandemic, research and life at the Biozentrum have largely returned to normal. This extraordinary time has taught us that much can be replaced by virtual formats, but face-to-face…

How organs develop and how they grow to the right size and shape are fundamental questions in developmental biology. The morphogen Dpp is a signaling molecule controlling the development of different organs with regard to…

LRBA deficiency is a rare and severe autoimmune disorder that was first described in 2012. This disease is caused by a genetic defect in the LRBA gene and is characterized by an impaired immune response and autoimmunity.…

Fitness clubs are booming: New gyms are springing up like mushrooms. More and more people are striving to build up and strengthen their muscles. But what exactly happens in the muscle during training? In their recent work,…

Be it through mucosa or the intestinal lining, different tissues and surfaces of our body are entry gates for bacterial pathogens. The first few seconds - the moment of touch - are often critical for successful infections.…

In Switzerland, about 650 new cases of liver cancer are diagnosed every year. The incidence of the malignant and aggressive liver cell carcinoma has doubled in the last 20 years, especially in developed countries. One…

Speaking from the soapbox November 2014 Brisk and sometimes bracing walks from his flat to and from the Biozentrum - this is the first thing that comes to mind to the famous Californian. In the early 1980ies the Nobel Prize…