Prof. Dr. Christoph Handschin

University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 710 Phone: +41 61 207 23 78
Curriculum Vitae

Administrative Assistant

Jny Wittker
Biozentrum, Room 709
Phone: +41 61 207 22 31
Fax: +41 61 207 22 08

Angelika Klarer
Kragenbau, Room G1058
Phone: +41 61 207 21 60
Fax: +41 61 207 21 89


New Sinergia project at Biozentrum for muscle wasting at high age

The Sinergia program of the Swiss National Science Foundation (SNSF) has...more

kids@science 2015 – Very young scientists at the Biozentrum

For the fourth time, the Biozentrum of the University of Basel is opening its...more

Sport makes muscles and nerves fit

Endurance sport does not only change the condition and fitness of muscles but...more

Research group Christoph Handschin

Regulation of skeletal muscle cell plasticity in health and disease

The molecular processes inherent in trained or diseased muscles may provide information about the development of muscle diseases.

Neuromuscular junctions of the sternocleidomastoid muscle (red: motor neurons, green: synaptic endplates)

Physical activity combined with a balanced diet is one of the most important measures to prevent or treat many diseases. Surprisingly, the mechanisms underlying the molecular adaptation responsible for the health-promoting effects of muscle training are still largely unknown.

Muscle functioning during training or in disease

We are interested in investigating the molecular processes that are set in motion during training and have a beneficial effect on our health. In addition, we aim at obtaining a greater understanding of exactly how muscle pathologies lead to dysfunction of the muscle, and how we can apply our knowledge of the developmental processes in trained muscles to the treatment of disease.

From molecule to patient

We combine state-of-the-art systems biology methods with innovative computational analysis of the transcriptional networks that control muscle cell plasticity. Together with work in muscle stem cells in culture, these approaches shed novel insights into muscle biology.

Improved understanding of muscle diseases

Our goal is to gain a better molecular understanding of healthy and diseased muscle. This might allow the development of new treatments for diseases that are associated with a lack of physical activity, such as type 2 diabetes. We also hope that we will be able to find therapeutic approaches to help patients who suffer from various types of muscle disease, including muscular dystrophies.