TOR signaling and control of cell growth Fig. 1: Architecture of human mTOR complex 1 Introduction Cell growth is highly regulated. Cells respond to nutrients or other appropriate growth stimuli by up-regulating…

TOR signaling and the control of cell growth Cell growth is a highly regulated, plastic process controlled by TOR-dependent pathways in response to nutrients, growth factors and energy. TOR is a major controller of cell…

Single-cell activities of bacterial pathogens during infection and treatment Bacterial infections are a major threat to human health. New antibiotics and vaccines are urgently required but progress has been slow. A major…

Skeletal muscle cell plasticity in health and disease The skeletal muscle is a highly plastic organ, able to adapt to contraction, nutrient availability and supply, ambient oxygen and temperature, as well as numerous other…

Research projects We investigate the physiology of bacterial pathogens ( Salmonella , Pseudomonas , Staphylococcus ) in infected rodent and human tissues, focusing on single-cell behavior and potential applications for novel…

Structure of molecular factories and regulatory complexes Metabolism summarizes all processes of biosynthesis and degradation of cellular building blocks. The necessary chemical conversions are catalyzed by a large number of…

Muscle aging Rapid advances in treating life-threatening, age-related diseases, such as cancer and cardiovascular disease, have extended human lifespan in many developed countries. However, greater longevity has meant more…

We study the cellular organization and regulation of metabolism by large macromolecular assemblies as well as giant microbial biosynthetic assembly lines. Our research builds on hybrid use of state-of-the-art cryo electron…

Research Projects Our team is comprised of people with different training: Some team members are trained in physics or mathematics, some are trained in molecular biology, and others are trained in interdisciplinary sciences…

Regulation of skeletal muscle cell plasticity in health and disease Skeletal muscle has an enormous capacity to adapt to external stimuli including physical activity, oxygen levels, ambient temperature, nutrient availability…