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Systems Biology of Salmonella and Shigella infection Infectious diseases represent a major worldwide threat to human health. Novel strategies to combat infectious disease are urgently needed because of rising resistance of…


Projects

TOR signaling and control of cell growth Fig. 1: Architecture of human mTOR complex 1 Introduction Cell growth is highly regulated. Cells respond to nutrients or other appropriate growth stimuli by up-regulating…


Research Group Dirk Bumann

The metabolism of pathogenic organisms as a target for intervention Infectious diseases are becoming more pressing health problems worldwide. Growing resistance of the pathogens increasingly restricts the effectiveness of…


Research Group Michael N. Hall

TOR signaling and the control of cell growth Cell growth is a highly regulated, plastic process controlled by TOR-dependent pathways in response to nutrients, growth factors and energy. TOR is a major controller of cell…


Research Group Christoph Handschin

Skeletal muscle cell plasticity in health and disease The skeletal muscle is a highly plastic organ, able to adapt to contraction, nutrient availability and supply, ambient oxygen and temperature, as well as numerous other…


Research Group Timm Maier

Structure of molecular factories and regulatory complexes Metabolism summarizes all processes of biosynthesis and degradation of cellular building blocks. The necessary chemical conversions are catalyzed by a large number of…


Muscle aging

Muscle aging Rapid advances in treating life-threatening, age-related diseases, such as cancer and cardiovascular disease, have extended human lifespan in many developed countries. However, greater longevity has meant more…


Projects

We study the cellular organization and regulation of metabolism by large macromolecular assemblies as well as giant microbial biosynthetic assembly lines. Our research builds on hybrid use of state-of-the-art cryo electron…


Projects

Research Projects Our team is comprised of people with different training: Some team members are trained in physics or mathematics, some are trained in molecular biology, and others are trained in interdisciplinary sciences…


Projects

Regulation of skeletal muscle cell plasticity in health and disease Skeletal muscle has an enormous capacity to adapt to external stimuli including physical activity, oxygen levels, ambient temperature, nutrient availability…