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Systems Biology of Salmonella and Shigella infection Infectious diseases represent a major worldwide threat to human health. Novel strategies to combat infectious disease are urgently needed because of rising resistance of…


Projects

TOR signaling and control of cell growth Fig. 1: Architecture of human mTOR complex 1 Introduction Cell growth is highly regulated. Cells respond to nutrients or other appropriate growth stimuli by up-regulating…


Why antibiotics can fail even against non-resistant bacteria

In certain infectious diseases, antibiotics are less effective than expected, as seen in infections caused by Salmonella bacteria, which can lead to illnesses such as typhoid fever. For many years, researchers believed that…


How cells defend their cytosol against bacteria: LPS ubiquitylation and other tricks

How cells defend their cytosol against bacteria: LPS ubiquitylation and other tricks Intracellular pathogens colonize specific subcellular niches, reflecting the pathogen's need for host factors and nutrients as well as its…


A protein that extends life of yeast cells

For about one hundred years it has been known that nutrient restriction and moderate stress can significantly prolong life. The researchers led by Prof. Mihaela Zavolan and Prof. Anne Spang, both at the Biozentrum of the…


Protected while sleeping: How pathogens survive antibiotic treatment

In recent years, the growing threat of antimicrobial resistance has become widely recognized. However, much less is known about drug-tolerant pathogens, which also complicate the treatment of bacterial infections. These…


Synopsis

Synopsis Antibiotic resistance has re-emerged as a critical problem of contemporary medicine. I will discuss the biological processes contributing to the spread of antibiotic resistance. In this talk, I will ask how…


Survival strategy of messenger RNAs during cellular sugar shortage

If a cell encounters a stress situation, whether it is due to nutrient restriction or osmotic shock, the cell reacts immediately to ensure its survival. Prof. Anne Spang’s research group at the Biozentrum of the University…


Yin and Yang: Two signaling molecules control growth and behavior in bacteria

Whether they are pathogens, deep-sea microbes or soil-dwelling organisms, in order to survive, microorganisms must be able to adapt rapidly to diverse changes in their environment, including nutrient depletion. Bacteria owe…


New discovery reveals how diatoms capture CO2 so effectively

Diatoms are too small to see with the naked eye, yet they are one of the most productive algae species in the ocean and play an important role in the global carbon cycle. Using photosynthesis, they absorb large amounts of…