Our body keeps bacterial pathogens under control by restricting their access to essential nutrients such as iron. Iron is crucial for all living organisms. When bacteria are deprived of iron, they stop growing and…
Whether they are pathogens, deep-sea microbes or soil-dwelling organisms, in order to survive, microorganisms must be able to adapt rapidly to diverse changes in their environment, including nutrient depletion. Bacteria owe…
In the world of microbes, peaceful coexistence goes hand in hand with fierce competition for nutrients and space. Certain bacteria outcompete rivals and fend off attackers by injecting them with a lethal cocktail using tiny,…
Diatoms are too small to see with the naked eye, yet they are one of the most productive algae species in the ocean and play an important role in the global carbon cycle. Using photosynthesis, they absorb large amounts of…
The liver is a vital organ with many important functions in the body. It metabolizes nutrients, stores energy, regulates the blood sugar level and plays a crucial role in detoxifying and removing harmful components and…
TOR signaling and the control of cell growth Cell growth is a highly regulated, plastic process controlled by TOR-dependent pathways in response to nutrients, growth factors and energy. TOR is a major controller of cell…
Single-cell activities of bacterial pathogens during infection and treatment Bacterial infections are a major threat to human health. New antibiotics and vaccines are urgently required but progress has been slow. A major…
Skeletal muscle cell plasticity in health and disease The skeletal muscle is a highly plastic organ, able to adapt to contraction, nutrient availability and supply, ambient oxygen and temperature, as well as numerous other…
Structure of molecular factories and regulatory complexes Metabolism summarizes all processes of biosynthesis and degradation of cellular building blocks. The necessary chemical conversions are catalyzed by a large number of…
Research projects We investigate the physiology of bacterial pathogens ( Salmonella , Pseudomonas , Staphylococcus ) in infected rodent and human tissues, focusing on single-cell behavior and potential applications for novel…
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