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Tackling the Achilles' heel of pneumonia-causing bacteria

According to the WHO, more than one million people worldwide die of pneumococcal infections every year. Young children, elderly and immunocompromised persons are particularly affected. After the introduction of…


Genetic engineering in research: same same, but different

The cell envelope is covered with a wide variety of receptor proteins. They are the sensors to the environment, perceive signals such as the availability of nutrients and transmit this information to the inside of the cell.…


Multiple treatments to slow age-related muscle wasting

We now live longer than at any point in human history, but to enjoy those extra years, we need to remain healthy, mobile and independent. With age, however, our muscles inevitably lose mass and strength. This age-related…


Virulence could be the Achilles heel of pathogens

Bacteria are masters of survival. Pathogens, for example, produce a range of molecules enabling them to infect their hosts and to evade the immune defense. The entero-pathogenic bacterium Salmonella enterica Typhimurium uses…


Bacterial nano-speargun as a precision weapon

No matter where you go, you always find someone there already. This is true for many living creatures but especially for bacteria. In order to be able to stand their ground and eliminate unwanted rivals, many bacteria rely…


Bacterial nanosized speargun works like a power drill

Millions of tiny microbes on leaves, stones or our skin jostle for space. And almost everywhere they have to compete for resources and nutrients. In the course of evolution, some bacteria have therefore developed a weapon to…


Immune defense without collateral damage

In the human body’s fight against bacterial pathogens, white blood cells are in the front line. They identify and ingest the invaders, and render them harmless using highly toxic substances. It is important that these…


Resistance can spread even without the use of antibiotics

Bacteria are becoming increasingly resistant to common antibiotics. Often, resistance is mediated by resistance genes, which can simply jump from one bacterial population to the next. It’s a common assumption that the…


BC2 Seminar Spring 2019

BC2 - Basel Computational Biology Seminar Series - Spring Semester 2018 18.02.2019 | Michael Manhart, ETH Zürich Michael Manhart Institute of Integrative Biology, ETH Zürich Zürich, Schweiz High-resolution dynamics of…


Living in Basel

Living and working in Basel Basel is one of the top fifteen cities with the highest quality of living worldwide according to the 2023 Mercer study . It is located in the heart of Europe and embedded in Europe’s most…