Prof. Dr. Timm Maier

Biozentrum
University of Basel
Klingelbergstrasse 50 / 70
CH - 4056 Basel
Biozentrum, Room 309 Phone: +41 61 207 21 76
Email: timm.maier-at-unibas.ch
Curriculum Vitae

Administrative Assistant

Alexandra Eberhardt
Biozentrum, Room 308
Phone: +41 61 207 20 81
Email: alexandra.eberhardt-at-unibas.ch

News

Assembly line: How bacteria and fungi produce drugs

Natural products from bacteria and fungi are an important source of current and...more

Urinary tract infection: How bacteria nestle in

Almost every second woman suffers from a bladder infection at some point in her...more

Architecture of mTOR protein complex solved

For a long time it has been known that the protein TOR – Target of Rapamycin –...more

Research group Timm Maier

Structure of molecular factories and regulatory complexes

Hybrid methods approaches provide fundamental insights into metabolic regulation and new perspectives for drug discovery.

The architecture of human target of rapamycin (TOR) complex 1.

Metabolism is the process of biosynthesis and degradation of cellular building blocks. The necessary chemical conversions are catalyzed by a large number of specific enzymes. Regulatory protein complexes tightly control the activity of key metabolic enzymes in response to environmental or cellular conditions. Abnormal function or regulation of metabolism are the cause of several diseases. Dysregulation of lipid metabolism, for example, is linked to the development of cancer and is a risk factor for cardiovascular diseases and diabetes.

 

 

Multienzymes and large regulatory assemblies

Our research focuses on the architecture and functional principles of multienzymes and regulatory protein complexes. Multienzymes integrate several catalytic activities into single enzymes and form huge biological factories. They are involved in central steps of metabolism, for example the lipid biosynthesis, but are also key players in microbial production of bioactive drug candidates. Large regulatory assemblies, such as the target-of-rapamycin (TOR) complex, integrate hormonal and nutrient signals for a tight control of cellular growth and proliferation.

Hybrid methods: approach to study protein function

We combine various experimental methods such as X-ray crystallography and electron microscopy with computational technologies. This so-called hybrid structural biology approach enables us to comprehensively study the organization, dynamics and functions of proteins.

Basis for therapeutic interventions

A fundamental understanding of metabolism and metabolic regulation is crucial for a targeted therapeutic intervention. The TOR complex and lipid biosynthesis multienzymes are important targets for fighting cancer. Structural studies provide general insights into the function of these proteins and directly highlight opportunities for drug discovery.