G protein-coupled receptors are embedded in the cell membrane and transmit signals from the outside to the inside of the cell. Because of their vast diversity and crucial role in the body, GPCRs are targeted by many drugs,…

Modelling urinary tract infections with organoids: insights into host–pathogen interactions in the bladder and prostate Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and a leading…

The population biology of bacterial pathogenicity: insights from Escherichia coli E. coli is a commensal of the human gut but also a major opportunistic pathogen causing of the order of a million deaths worldwide each year.…

Navigating Complex Paths: Insights into the Molecular Mechanism of Diatom Gliding Diatoms are unicellular algae renowned for their ornate silica cell walls, but equally striking is their ability to adhere and glide rapidly…

Insights into endolysosomal membrane homeostasis The biogenesis of endosomes and lysosomes is tightly connected to several membrane trafficking pathways from the Golgi or the plasma membrane. In addition, autophagosomes…

Microbial symbionts as sources of evolutionary innovations in beetles Symbiotic associations with microbes are important driving forces of evolutionary innovation. The megadiverse insect order Coleoptera, the beetles, are…

The issue of intestinal bacteria is a complex one. On the one hand, we are dependent on the microorganisms because they are the ones that digest the food in our intestine. On the other hand, there are also numerous pathogens…

While Myc concentrations in muscle are normally low, they rise with growth stimuli, such as exercise. Based on this observation and the fact that Myc stimulates many growth processes, researchers hypothesized that Myc was…

The population biology of bacterial pathogenicity: insights from Escherichia coli E. coli is a commensal of the human gut but also a major opportunistic pathogen causing of the order of a million deaths worldwide each year.…

M. tuberculosis phenotypic diversity in vivo Mycobacterium tuberculosis (Mtb) exhibits remarkable phenotypic diversity, enabling its adaptation to various host environments. The diversity of in vivo niches at granuloma,…