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Survival trick: Pathogen taps iron source in immune cells

Our body keeps bacterial pathogens under control by restricting their access to essential nutrients such as iron. Iron is crucial for all living organisms. When bacteria are deprived of iron, they stop growing and…


GPS for chromosomes: Reorganization of the genome during development

Our body is made up of a wide variety of cells with the most diverse functions. Irrespective of being heart, liver or nerve cells, however, they all contain the same genetic information. The reason why cells develop…


Yin and Yang: Two signaling molecules control growth and behavior in bacteria

Whether they are pathogens, deep-sea microbes or soil-dwelling organisms, in order to survive, microorganisms must be able to adapt rapidly to diverse changes in their environment, including nutrient depletion. Bacteria owe…


Engineered T cells promote long-term organ transplant acceptance

When someone is confronted with ‘foreign’ material, be it viruses, bacteria, fungi, but also donor organs following transplantation, immune cells called T cells come into action to inactivate and destroy the ”foreign”…


OMERO Image Data Management

IMCF OMERO Image Management System OMERO is a biological image data management system designed to support the vast amount of imaging data a scientist may work with and to provide easy ways of accessing, showing and working…


Bacteria free themselves with molecular “speargun”

Tularemia is an infectious disease that mostly affects rabbits and rodents, but also humans can become infected. The cause of this serious disease is the bacterium Francisella tularensis . The infection biologists led by…


Lucia Du

Lucia Du, Postdoc, Group Schier Can you provide us some insights into your research? Development is a remarkably robust process that results in the generation of organs with reproducible size, shape and functions. My…


Tackling the Achilles' heel of pneumonia-causing bacteria

According to the WHO, more than one million people worldwide die of pneumococcal infections every year. Young children, elderly and immunocompromised persons are particularly affected. After the introduction of…


Virulence could be the Achilles heel of pathogens

Bacteria are masters of survival. Pathogens, for example, produce a range of molecules enabling them to infect their hosts and to evade the immune defense. The entero-pathogenic bacterium Salmonella enterica Typhimurium uses…


Speed controllers for protein production

Proteins perform various jobs in cells, they catalyze thousands of biochemical reactions, relay signals and are required for building cellular structures and transport processes. Within every single cell of our body vast…