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A bacterial toxin facilitating chronic infection

When pathogens invade our body the immune system is put on alert. The body’s immune cells are recruited to the site of infection and an inflammatory reaction is initiated to rapidly eliminate the invaders. Some pathogens,…


Protective shield: How pathogens withstand acidic environments in the body

Each year, thousands of patients in Swiss hospitals become infected with dangerous pathogens that can hardly be controlled with antibiotics. The methicillin-resistant bacterium Staphylococcus aureus , MRSA for short, is…


Engineered enzymes: String pullers in cell communication

Cells are the building blocks of all living creatures. In order to form a complex organism and stay healthy, cells need to communicate with each other and integrate the response within themselves. A group of enzymes,…


Numerous genes important for muscle-nerve connection identified

Walking, breathing, or writing – these movements would not be possible without our muscles. The instructions are given by the nerves that communicate with the muscles through neuromuscular junctions. Damage to or loss of…


PhD at a Glance

PhD at a Glance Young scientists from around the world choose the Biozentrum – one of the world-leading Life Sciences institutes – to do their PhD. There are many reasons why they do so. Join us and become part of our…


Survival trick: Pathogen taps iron source in immune cells

Our body keeps bacterial pathogens under control by restricting their access to essential nutrients such as iron. Iron is crucial for all living organisms. When bacteria are deprived of iron, they stop growing and…


Like a zipper – How cells form new blood vessels

The blood vessels form a widely ramified supply system that passes through our body from head to toe. They serve as pathways for blood cells and transport oxygen as well as nutrients into each individual organ. In the…


Acrobatic duo in the cells

Misfolded proteins are non-functional and cause cell damage. In order to prevent this, there is a whole arsenal of proteins – called chaperones – that assist with folding and carry out quality control. In the bacterium…


Nanomachine keeps cellular power plants healthy

Every single cell of our body contains hundreds of tiny power plants, the mitochondria, which produce the energy required by the body, whether it be for walking, digesting or to ponder ideas. This inevitably generates…


Yin and Yang: Two signaling molecules control growth and behavior in bacteria

Whether they are pathogens, deep-sea microbes or soil-dwelling organisms, in order to survive, microorganisms must be able to adapt rapidly to diverse changes in their environment, including nutrient depletion. Bacteria owe…