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Enigma of fatty acid metabolism solved: Enzyme shape controls its activity

Fats are highly diverse molecules that serve as fuel and energy storage, and they constitute the building blocks for cell membranes, hormones and messengers. Despite the diversity of fats, all the fatty acids contained…


Diversity in the brain: New genes create new cell types

With its hundreds of thousands of nerve cells, the vertebrate brain is the most complex organ in the animal kingdom. During vertebrate evolution not only have the number of neurons and consequently the volume of the brain…


Researchers discover new anti-cancer protein

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled in Switzerland. Hepatocellular carcinoma is usually diagnosed at…


Blood vessel formation: how the vascular cells respond to blood pressure

Throughout our body there is a dense, widely ramified network of blood vessels. It is estimated to be about 150,000 kilometers in length. The vessels supply all cells, even those in most far away regions of the body with…


Neutralizing antibodies control bacterial infection

Bartonella are bacteria that are transmitted from blood-sucking insects to mammals, including humans. There they enter the red blood cells and cause various symptoms. An example of such a human infection with a worldwide…


Gene transfer keeps bacteria fit

Bartonella are bacteria that can cause diverse infectious diseases in man, such as cat-scratch disease. In order to prevent the accumulation of mutations during the infection cycle, pathogens require efficient DNA repair…


New way to improve the efficacy of innovative RNA therapies

In modern medicine, personalized therapies are becoming increasingly important – particularly in the treatment of genetic diseases. One such promising approach is the use of so-called antisense oligonucleotides (ASOs). These…


New insights into blood vessel formation

Blood vessels run throughout the entire body, delivering nutrients and oxygen through the circulating blood. During vessel formation, cells first form local lumens, which then fuse to form a continuous tubular network. The…


Protected while sleeping: How pathogens survive antibiotic treatment

In recent years, the growing threat of antimicrobial resistance has become widely recognized. However, much less is known about drug-tolerant pathogens, which also complicate the treatment of bacterial infections. These…


Should I stay or should I go: Hospital germ’s dual strategy

In Switzerland, it is not uncommon for a patient to develop an infection during a hospital stay. One reason for this is insufficient hygiene, as shown recently in a study by the Swiss Agency for Therapeutic Products,…