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Resistant cancer cells: 3D structure of a drug transporter decoded

In the course of evolution, the human body has developed diverse strategies to protect itself from harmful substances. In the intestine, the placenta and also in the blood-brain barrier are tiny transport proteins, which…


Tagged for arrest: “Barcode” determines receptor’s fate.

Odors, light, hormones and a tremendous variety of signaling molecules are recognized by a large family of cell receptors, known as G protein-coupled receptors (GPCRs). They are located on the cell surface and transduce…


Novel antibiotic deceives bacteria through mimicry

An increasing number of bacterial pathogens are resistant to antibiotics. And the most dangerous pathogens share a common feature: a double membrane that is difficult to penetrate. Even when antibiotic agents are able to…


How the key protein mTOR controls cell growth

Cells proliferate by dividing repeatedly. Each cell division produces two daughter cells, which must first grow to a certain size before they can divide, too. This requires an increased production of cell components,…


Synapses of the reward system at stake in autistic disorders

In all mammals, the reward system is a fundamental brain circuit that reinforces certain behaviours by providing the motivation necessary for their achievement. Search for food, learning or emotional behaviours are for…


Cholera bacteria form aggressive biofilm to kill immune cells

Many bacteria adopt a fascinating defense strategy by forming communities on surfaces, known as biofilms. We encounter such biofilms in our daily lives, for example, as dental plaque in the mouth, slimy films on stones in…


Fish-out-of-water: How killifish embryos adapted their development

Extremely dry – the habitat of killifish The turquoise killifish inhabits areas characterized by extreme conditions. The species, native to Africa, can survive prolonged periods of drought due to its unique life cycle.…


High-speed storage of CO2 discovered in bacteria

The unusual enzyme HDCR produces formic acid from gaseous hydrogen (H2) and carbon dioxide (CO 2 ), thus removing CO 2 from the environment and storing it in the cell. In this process, HDCR transfers electrons from hydrogen…


Sophisticated swarming: Bacteria support each other across generations

In nature, bacteria usually live in communities. They collectively colonize our gut, also known as the gut microbiome, or form biofilms such as dental plaque. Living in communities provides many advantages to the individual…


Under control to the very end – how our cells kill themselves

Cell death is crucial for all organisms. Damaged cells or cells infected with viruses or bacteria eliminate themselves by starting a built-in “suicide” program, which prevents the development of tumors and the spread of…